Preservation of Cardiac Xenografts in a Model of Infant Human Cardiac Transplantation
Del Nido cardioplegia solution when combined with short graft ischemic times demonstrates promising outcomes to avoid primary graft dysfunction for cardiac xenografts in a small animal model of life-sustaining orthotopic cardiac xenotransplantation. Ex vivo perfusion systems may be unnecessary for successful clinical implementation of this evolving technology.
Authors
- Julie Fenske (ORCID: https://orcid.org/0000-0002-7520-5110)
- Joe H. Simmons (ORCID: https://orcid.org/0000-0003-1815-6831)
- David C. Cleveland (ORCID: https://orcid.org/0000-0002-7954-3512)
- Chace Mitchell (ORCID: https://orcid.org/0000-0002-1578-726X)
- Carolyn L. Hodo (ORCID: https://orcid.org/0000-0003-4113-7081)
- C. Vo (ORCID: https://orcid.org/0000-0002-6286-4635)
- Julie Juliani
- John D. Cleveland
- Kanwarpal Bakshi
Institutions
- University of Southern California (US)
- Children's Hospital of Los Angeles (US)
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Xenotransplantation
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1111/xen.70009
- Citations
- 5
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- National Institutes of Health