Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns
rTMD1 demonstrates substantial therapeutic potential in treating corneal alkali burns by reducing inflammation, promoting tissue repair, controlling fibrosis, and inhibiting neovascularization. These findings support the further development of rTMD1 as a promising treatment for corneal burns and possibly other inflammatory ocular conditions.
Authors
- I‐Chen Peng (ORCID: https://orcid.org/0000-0001-5826-500X)
- Yi-Hsun Huang
- Chun‐Hsiang Chang
Institutions
- National Cheng Kung University Hospital (TW)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1167/iovs.66.1.21
- Citations
- 6
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.16
Funders
- National Science and Technology Council
- Centre for Blood Research, University of British Columbia