The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19
We provide novel evidence on the neuroanatomical basis of fatigue vulnerability and emphasize that acute fatigue is an important link between early GMV in the frontal-limbic regions and comorbid neuropsychiatric symptoms at baseline and 3 months after infection. Our findings highlight the role of the frontal-limbic system in predisposing individuals to develop post-COVID fatigue.
Authors
- Huawen Zhang
- Tao Lu (ORCID: https://orcid.org/0000-0002-8247-8387)
- Heping Zhou
- Bin Guo (ORCID: https://orcid.org/0000-0001-5950-8974)
- Hui Ma (ORCID: https://orcid.org/0000-0002-7107-810X)
- Xuan Niu (ORCID: https://orcid.org/0000-0002-1580-0209)
- Bo Wang (ORCID: https://orcid.org/0000-0002-3231-1167)
- Baoqi Wang (ORCID: https://orcid.org/0000-0002-8410-6712)
- Junya Mu (ORCID: https://orcid.org/0000-0002-5135-1156)
- Haiyang Liu (ORCID: https://orcid.org/0000-0002-6900-3491)
- Yuchen Zhang (ORCID: https://orcid.org/0000-0002-5411-6063)
- Ming Zhang (ORCID: https://orcid.org/0000-0002-6546-2762)
- Shaohui Ma (ORCID: https://orcid.org/0009-0006-8087-0277)
- Jixin Liu (ORCID: https://orcid.org/0000-0002-4239-1201)
- Zhaoyao Luo
- Pang Du
- Wenrui Bao
Institutions
- Xidian University (CN)
- Yanan University Affiliated Hospital (CN)
- Xi'an Medical University (CN)
- Ankang City Central Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
- Hanzhong Central Hospital (CN)
- Baoji City Central Hospital (CN)
- Shangluo Central Hospital (CN)
- Yulin University (CN)
- Ningbo No.6 Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- NeuroImage
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1016/j.neuroimage.2025.121011
- Citations
- 4
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- National Natural Science Foundation of China