A Transcriptomic Signature of Depressive Symptoms in Late Life
Building on recently published single-nucleus profiling, we present the largest-ever study of transcriptomic correlates of depressive symptoms in late life, revealing new insights into sex-specific regulators. <i>PWAR1</i> and <i>CTDSPL2</i> were identified as putative markers of late-life depression in the dorsolateral prefrontal cortex and warrant further study.
Authors
- Hongxin Dong (ORCID: https://orcid.org/0000-0002-2469-070X)
- Thomas Delong (ORCID: https://orcid.org/0000-0002-3199-9385)
- Melissa Misztal (ORCID: https://orcid.org/0000-0002-1191-4364)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Mu Yang (ORCID: https://orcid.org/0000-0001-7084-029X)
- Jeffrey T. Dunn (ORCID: https://orcid.org/0000-0002-0287-1606)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Stuart Matan-Lithwick
- Daniel Fisher (ORCID: https://orcid.org/0000-0003-3271-8327)
- Daniel Felsky (ORCID: https://orcid.org/0000-0003-1831-9848)
- Shreejoy J. Tripathy (ORCID: https://orcid.org/0000-0002-1007-9061)
- Yanling Wang (ORCID: https://orcid.org/0000-0001-6645-9883)
Institutions
- Northwestern University (US)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- University of Washington (US)
- Columbia University Irving Medical Center (US)
- Public Health Ontario (CA)
- Rush University (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100448
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Krembil Foundation
- National Institutes of Health
- Canadian Institutes of Health Research