Gut microbiome dysbiosis is not associated with portal vein thrombosis in patients with end-stage liver disease: a cross-sectional study
We observed profound differences in gut microbiota between patients with ESLD and controls, but minimal differences between patients with ESLD with or without PVT. In our cohort, a gut-derived proinflammatory state was not associated with presence of PVT in patients with ESLD.
Authors
- Eleonora Anna Margaretha Festen (ORCID: https://orcid.org/0000-0002-3255-6930)
- Margery A. Connelly (ORCID: https://orcid.org/0000-0002-3917-592X)
- Hans Blokzijl (ORCID: https://orcid.org/0000-0003-4240-7506)
- Naomi Karmi (ORCID: https://orcid.org/0000-0001-8519-6812)
- Rali R Aleksandrova
- Ranko Gaćeša (ORCID: https://orcid.org/0000-0003-2119-0539)
- Lianne M. Nieuwenhuis (ORCID: https://orcid.org/0000-0003-1159-787X)
- J. Casper Swarte (ORCID: https://orcid.org/0000-0002-3709-9193)
- Johannes R. Björk (ORCID: https://orcid.org/0000-0001-9768-1946)
- Vincent E. de Meijer (ORCID: https://orcid.org/0000-0002-7900-5917)
- Rinse Karel Weersma (ORCID: https://orcid.org/0000-0001-7928-7371)
- Ton Lisman (ORCID: https://orcid.org/0000-0002-3503-7140)
- Shuyan Zhang (ORCID: https://orcid.org/0000-0003-0237-0067)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- LabCorp (United States) (US)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1016/j.jtha.2024.12.036
- Citations
- 6
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 7.93
Funders
- Chiesi Farmaceutici
- Astellas Pharma
- Universitair Medisch Centrum Groningen
- Ministerie van Economische Zaken en Klimaat