Keratin 1 modulates intestinal barrier and immune response <i>via</i> kallikrein kinin system in ulcerative colitis
KRT1 inhibits BK expression, suppresses inflammatory cytokines, and enhances markers of intestinal barrier function, thus ameliorating colonic damage and maintaining barrier integrity. KRT1 is a viable therapeutic target for UC.
Authors
- Lanqing Ma (ORCID: https://orcid.org/0000-0002-5578-6958)
- Yanmiao Qi (ORCID: https://orcid.org/0009-0002-3212-0632)
- Maojuan Li
- Yinghui Zhang (ORCID: https://orcid.org/0000-0002-4588-7819)
- Yinglei Miao (ORCID: https://orcid.org/0000-0001-8193-5198)
- Xiang-Qian Dong
- Juan Luo
Institutions
- Yunnan University (CN)
- Kunming Medical University (CN)
- Second People's Hospital of Yunnan Province (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.3748/wjg.v31.i6.102070
- Citations
- 3
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 4.88