Oral Cancer's New Enemy: Goniothalamus umbrosus Targets Oral Squamous Cell Carcinoma and Spare Human Gingival Fibroblast Cells
The findings show that GUHE was more selective in inhibiting the proliferation of oral cancer cells than GUME by exerting moderate cytotoxicity on OSCC cell lines and weak cytotoxicity in HGF cells, while GUME exerted moderate cytotoxicity on both. These findings suggest a more targeted anticancer effect by GUHE as compared with cisplatin, which exerted nonselective cytotoxic activity. These findings provide a groundwork for the development of more targeted plant-based treatment for oral cancer.
Authors
- Muhanad Ali Hamdon Kashmola (ORCID: https://orcid.org/0000-0002-3563-5431)
- Basma Ezzat Mustafa Al-Ahmad (ORCID: https://orcid.org/0000-0001-9953-4536)
- Khairani Idah Mokhtar (ORCID: https://orcid.org/0000-0002-7456-7865)
- Nik Mohd Mazuan Nik Mohd Rosdy (ORCID: https://orcid.org/0000-0002-2322-1004)
- Widya Lestari
- Najib Aziz (ORCID: https://orcid.org/0000-0002-3522-3840)
Institutions
- Alrafidain University College (IQ)
- International Islamic University Malaysia (MY)
- Hospital Sungai Buloh (MY)
- Universiti Teknologi MARA (MY)
Publication Details
- Journal
- European Journal of Dentistry
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1055/s-0044-1801278
- Citations
- 2
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 2.22