Genetic insights into the risk of hip osteoarthritis on stroke: A single-variable and multivariable Mendelian randomization
The study demonstrated that elevated hip osteoarthritis, as predicted by genetic factors, was potential associated with an increased risk of any stroke, any ischemic stroke, and cardioembolic stroke, but showed no correlation with hypertension, alcoholic drinks per week, cigarettes per day, type 2 diabetes, C-reactive protein, body mass index levels, and rheumatoid arthritis.
Authors
- Wuhua Ma (ORCID: https://orcid.org/0000-0003-1277-1681)
- Zhi Zhang (ORCID: https://orcid.org/0000-0001-6256-9516)
- Yuewen He (ORCID: https://orcid.org/0000-0002-4078-5100)
- Yong Lian (ORCID: https://orcid.org/0000-0002-5289-5219)
- Yong Wang (ORCID: https://orcid.org/0000-0003-4061-7956)
- Kai Meng (ORCID: https://orcid.org/0000-0002-3939-273X)
- Hao Liu (ORCID: https://orcid.org/0000-0003-4271-1567)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Shandong Mental Health Center (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1371/journal.pone.0313032
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Bureau