Impact of the Inflammatory Burden Index on Prognosis After Hepatectomy for Colorectal Liver Metastasis

Background/AimThe aim of this study was to investigate the prognostic impact of the inflammatory burden index (IBI), a novel inflammation-based biomarker, in patients with colorectal liver metastases (CRLM) after hepatic resection.Patients and MethodsOne hundred fifty patients with CRLM who underwent hepatectomy were retrospectively analyzed. The IBI was defined as C-reactive protein × neutrophil count/lymphocyte count. The relationship of the IBI with overall survival was investigated by univariate and multivariate analyses.ResultsSeventy-three (49%) patients had a high IBI (>3.45). In univariate analysis, overall survival was significantly worse in patients with lymph node metastases (<i>P</i> = 0.048), high NLR (<i>P</i> = 0.03), and high IBI (<i>P</i> < 0.01). In multivariate analysis, high IBI (<i>P</i> = 0.048) was an independent and significant predictor of overall survival. Patients with a high IBI had more postoperative complications compared with those with a low IBI (<i>P</i> < 0.01).ConclusionThe IBI was a strong predictor for both short- and long-term outcomes in patients who underwent hepatic resection for CRLM.