Cortico-Muscular Phase Connectivity During an Isometric Knee Extension Task in People With Early Parkinson’s Disease
The EEG power spectrum revealed no cohort differences in the beta-band. EMG also showed no differences up to 80 Hz. However, the combined EEG-EMG analysis uncovered reduced beta phase coherence in people with early PD during the motor task. CM phase coherence exhibited distinct scalp topography and frequency ranges compared to the EEG power spectrum, suggesting different mechanisms for pathological beta increase and CM connectivity. Additionally, phase dynamics modelling indicated stronger directional coupling from the cortex to the active muscle and less prominent phase coupling across people with PD. Despite high inter-individual variability, these metrics may prove useful for personalized assessments, particularly in people with heightened CM connectivity.
Authors
- Uroš Marušič (ORCID: https://orcid.org/0000-0002-7420-2137)
- Paolo Manganotti (ORCID: https://orcid.org/0000-0001-5305-6268)
- Klaus Gramann (ORCID: https://orcid.org/0000-0003-2673-1832)
- Nina Omejc (ORCID: https://orcid.org/0000-0003-1212-1566)
- Sašo Džeroski (ORCID: https://orcid.org/0000-0003-2363-712X)
- Manca Peskar (ORCID: https://orcid.org/0000-0001-8524-5346)
- Tomislav Stankovski (ORCID: https://orcid.org/0000-0003-2974-2836)
- Miloš Kalc (ORCID: https://orcid.org/0000-0001-7002-2924)
Institutions
- University of Trieste (IT)
- Alma Mater Europaea (SI)
- Jožef Stefan Institute (SI)
- University of Maribor (SI)
- Ospedale di Cattinara (IT)
- Technische Universität Berlin (DE)
- Lancaster University (GB)
- Ss. Cyril and Methodius University in Skopje (MK)
Publication Details
- Journal
- IEEE Transactions on Neural Systems and Rehabilitation Engineering
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1109/tnsre.2025.3527578
- Citations
- 3
- Primary Topic
- Muscle activation and electromyography studies
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- HORIZON EUROPE Framework Programme