Impact of Adding <i>N</i>-hexylamine to Nickel Metallophotoredox C–N Coupling to Form Diarylamines
The mechanistic understanding of how alkylamines impact Ni-metallophotoredox C-N coupling to form diarylamines remains unclear. In this study, 12-alkylamines were evaluated as additives to determine their effects on the synthesis of diarylamines in a flow photochemical system. Notably, <i>n</i>-hexylamine demonstrated the most significant promotional effect. Spectroscopic studies and experimental data reveal <i>n</i>-hexylamine substitutes DABCO as a Ni catalyst ligand, enhancing yields particularly in sterically hindered arylamines.
Authors
- Fujun Li (ORCID: https://orcid.org/0009-0009-2888-4841)
- A. A. Miskevich (ORCID: https://orcid.org/0000-0001-7002-5578)
- Shengyang Tao (ORCID: https://orcid.org/0000-0002-0567-8860)
- Wenbo Yang (ORCID: https://orcid.org/0000-0003-2156-0560)
- Haiyang Wang (ORCID: https://orcid.org/0000-0001-7660-8133)
- Lijing Zhang (ORCID: https://orcid.org/0000-0003-1126-8785)
- Yuchao Wang (ORCID: https://orcid.org/0000-0002-4366-8663)
- Valery A. Loiko (ORCID: https://orcid.org/0000-0003-0852-0556)
Institutions
- National Academy of Sciences of Belarus (BY)
- Dalian University of Technology (CN)
- Dalian University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1021/acs.joc.4c02106
- Citations
- 2
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Belarusian Republican Foundation for Fundamental Research
- Dalian High-Level Talent Innovation Program
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Fundamental Research Funds for the Central Universities