Constitutive surface expression of the thromboxane A2 receptor is Pim kinase-dependent
Pim kinase inhibition may offer a novel therapeutic approach to limit cellular responses to thromboxane A2, independent of cyclooxygenase inhibition and direct antagonism of the receptor.
Authors
- Maria Blanco-Lopez (ORCID: https://orcid.org/0009-0004-7180-2964)
- James L. Hutchinson (ORCID: https://orcid.org/0000-0001-6542-0151)
- Amanda J. Unsworth (ORCID: https://orcid.org/0000-0003-3809-5984)
- Stuart J. Mundell (ORCID: https://orcid.org/0000-0001-7754-3271)
- Sophie H. Nock (ORCID: https://orcid.org/0000-0002-1964-7133)
- Khalid M. Naseem (ORCID: https://orcid.org/0000-0002-3870-8747)
- Sarah Jones (ORCID: https://orcid.org/0000-0001-8154-3928)
Institutions
- Manchester Metropolitan University (GB)
- University of Leeds (GB)
- University of Bristol (GB)
- Leeds Beckett University (GB)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jtha.2024.09.013
- Citations
- 7
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- CSL Behring
- British Heart Foundation