Effect of electroacupuncture on vascular remodeling in rats with cerebral ischemia by regulating irisin based on VEGF/Akt/eNOS signaling pathway
EA upregulated irisin expression, reaching a peak after 7 days of EA and then stabilizing. EA facilitated vascular remodeling after cerebral ischemia, and this might be associated with the activation of the irisin-mediated VEGF/Akt/eNOS signaling pathway.
Authors
- Kewei Yu (ORCID: https://orcid.org/0000-0002-2028-0957)
- Xiaoman Deng (ORCID: https://orcid.org/0000-0002-3038-3300)
- Yangrui Wang (ORCID: https://orcid.org/0000-0002-0689-7723)
- Shixiu Wu (ORCID: https://orcid.org/0000-0001-8286-6673)
- Nianhong Wang (ORCID: https://orcid.org/0000-0002-3482-7327)
- Yi Wu
- Chong Guan (ORCID: https://orcid.org/0000-0002-4877-027X)
- Ya-Shuo Feng
- Xuan Sha
- Tingting Zhang (ORCID: https://orcid.org/0000-0001-8246-8528)
- Hongyu Xie (ORCID: https://orcid.org/0000-0001-6386-8083)
- Lijuan Zhao (ORCID: https://orcid.org/0000-0002-1442-1266)
- W. Ding (ORCID: https://orcid.org/0000-0002-4614-956X)
- Dongyan Xu
- Lu Cao
- Li Liu (ORCID: https://orcid.org/0000-0002-0504-418X)
Institutions
- Fudan University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111192
- Citations
- 5
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- National Natural Science Foundation of China