Protocol-Driven Insulin Regimen Improves Parenteral Nutrition-Induced Hyperglycemia and Provides Trend Toward Meeting Dextrose Calorie Goals While Posing a Low Hypoglycemic Risk

Parenteral nutrition (PN)-induced hyperglycemia is a well-documented obstacle among hospitalized patients. We retrospectively investigated the effects of a protocol-driven insulin regimen (IR) compared with provider discretion (PD) insulin management for PN-induced hyperglycemic incidents. There were no statistical differences for duration to euglycemia, proportion meeting PN dextrose goal (PN goal), or hypoglycemia; however, a trend of achieving PN goal was noted at 63.64% (IR) and 34.62% (PD) and the incidence of euglycemia was higher with IR (90.91%) compared with PD methods (42.31%, P = .01). An IR may improve PN-induced hyperglycemia with a trend of achieving PN goals compared with PD methods.