ANXA10 sensitizes microsatellite instability-high colorectal cancer to anti-PD-1 immunotherapy via assembly of HLA-DR dimers by regulating CD74
Our results provided a novel molecular marker ANXA10 to identify benefit population of MSI-H CRC for improving efficacy of anti-PD-1 and contributed to selection of treatment strategies.
Authors
- Ruichuan Shi (ORCID: https://orcid.org/0000-0001-6903-9825)
- Xiujuan Qu (ORCID: https://orcid.org/0009-0005-9366-2314)
- Dongni Wang (ORCID: https://orcid.org/0000-0002-7130-6408)
- Ti Wen (ORCID: https://orcid.org/0000-0002-6688-211X)
- Yiting Sun (ORCID: https://orcid.org/0000-0001-5842-2618)
- Danni Li (ORCID: https://orcid.org/0000-0002-1882-7394)
- Ce Li (ORCID: https://orcid.org/0000-0003-1465-4905)
- Bowen Yang (ORCID: https://orcid.org/0000-0001-5218-7805)
- Fuqiang Zhang (ORCID: https://orcid.org/0000-0003-1666-367X)
- Xiaoyu Guo (ORCID: https://orcid.org/0000-0003-0874-6432)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- First Hospital of China Medical University (CN)
- Ministry of Education (KN)
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2025-01-10
- DOI
- https://doi.org/10.1007/s10565-024-09982-2
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09