A Rare Case of Cystic Angiomatosis Involving the Bones: Our Experience and Review of Literature

Cystic angiomatosis (CA) is a rare, benign, multifocal disorder of mixed lesions (lytic, sclerotic) developed due to maldeveloped lymphatic and vascular systems. In majority of cases, it is identified fortuitously and mimicked as metastatic malignant lesions. In such cases, differential diagnosis followed by treatment is identified to be critical for stabilizing the disease and its prognosis. We reported a case of a 24-year-old female who presented to our center with complaints of lower back ache (∼4-6 weeks), intermittent pain in the abdomen, and occasional dyspnea on exertion. Imaging studies revealed mild lytic lesions and small-sized cysts in the spine, bones, and spleen. Investigations confirmed CA and follow-up treatment was given using zoledronic acid (4 mg/intravenous) every 3 months to stabilize the bone lesions. CA is a heterogeneous disease with unpredictable progression and uncertain treatment. So, it is highly recommended to disseminate research findings of all such rare cases to find any new pathophysiological findings and establish an effective treatment.