Neutrophil Extracellular Traps (NETs) as a Potential Target for Anti-Aging: Role of Therapeutic Apheresis
Neutrophil extracellular traps (NETs) are large structures composed of chromatin, histones and granule-derived proteins released extracellularly by neutrophils. They are generally considered to be a part of the antimicrobial defense strategy, preventing the dissemination of pathogens. However, overproduction of NETs or their ineffective clearance can drive various pathologies, many of which are associated with advanced age and involve uncontrolled inflammation, oxidative, cardiovascular and neurodegenerative stress as underlying mechanisms. Targeting NETs in the elderly as an anti-aging therapy seems to be a very attractive therapeutic approach. Therapeutic apheresis with a specific filter to remove NETs could be a promising strategy worth considering.
Authors
- Stefan R. Bornstein (ORCID: https://orcid.org/0000-0002-5211-2536)
- Richard Siow (ORCID: https://orcid.org/0000-0003-4603-9763)
- Norbert Weiss (ORCID: https://orcid.org/0000-0002-0040-1109)
- Ulrich Julius (ORCID: https://orcid.org/0000-0002-1584-5693)
- Roman N. Rodionov (ORCID: https://orcid.org/0000-0002-7470-7776)
- Karin Voit-Bak
- Jens Passauer
- Natalia Jarzebska (ORCID: https://orcid.org/0000-0002-1275-2942)
- Yannick P. Kok (ORCID: https://orcid.org/0000-0001-7041-5496)
- Andrew Aswani
- R. Kirk Rettig
- Richard Straube (ORCID: https://orcid.org/0009-0000-6257-6775)
- Jürgen Gräßler
- Sergey Tselmin
- Philip Mavberg
- Anna Mücke
Institutions
- Flinders University (AU)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Flinders Medical Centre (AU)
- University of Oxford (GB)
- University Hospital Carl Gustav Carus (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Hormone and Metabolic Research
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1055/a-2444-3422
- Citations
- 5
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Universität Zürich