Maternal autoimmune systemic connective tissue disease and vasculitis and electrocardiographic findings in the offspring

In this population-based study, no significant overall differences in ECG parameters were found between neonates exposed to maternal CTD or vasculitis and unexposed neonates. However, neonates exposed to maternal antiphospholipid syndrome had significantly longer QRS- and QTc intervals than unexposed neonates. The potential clinical implications of these findings are unknown and, combined with the limitations of this study, warrant further investigation in larger cohorts.

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Publication Details

Journal
Journal of Autoimmunity
Published
2025-01-01
DOI
https://doi.org/10.1016/j.jaut.2025.103356
Primary Topic
Systemic Lupus Erythematosus Research
Type
article
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article

Maternal autoimmune systemic connective tissue disease and vasculitis and electrocardiographic findings in the offspring

Anna Axelsson Raja, Alex Hørby Christensen, Heather A. Boyd, Anne‐Sophie Sillesen et al.
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Maternal autoimmune systemic connective tissue disease and vasculitis and electrocardiographic findings in the offspring

Anna Axelsson Raja, Alex Hørby Christensen, Heather A. Boyd, Anne‐Sophie Sillesen, Sofie Dannesbo, Henning Bundgaard, Ruth Ottilia Birgitta Vøgg, Kasper Karmark Iversen, Maria Munk Pærregaard, Karen Ingrid Schreiber, Terese Frellesen Neumann, Steen Andersen
article en

Abstract

In this population-based study, no significant overall differences in ECG parameters were found between neonates exposed to maternal CTD or vasculitis and unexposed neonates. However, neonates exposed to maternal antiphospholipid syndrome had significantly longer QRS- and QTc intervals than unexposed neonates. The potential clinical implications of these findings are unknown and, combined with the limitations of this study, warrant further investigation in larger cohorts.

Journal of AutoimmunityVol. 150
Statens Serum Institut (DK), Copenhagen University Hospital (DK), Gentofte Hospital (DK), Rigshospitalet (DK), Danish National Research Foundation (DK)
Good health and well-being
Openalex Percentile: Top 99%
Systemic Lupus Erythematosus Research
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Maternal autoimmune systemic connective tissue disease and vasculitis and electrocardiographic findings in the offspring — Anna Axelsson Raja, Alex Hørby Christensen, et al. · Journal of Autoimmunity (2025) | TGRS Research Map | TGRS