Association of Medial Temporal Lobe Cerebrovascular Reactivity and Memory Function in Older Adults With and Without Cognitive Impairment
Deficits in medial temporal CVR are observed in older adults with MCI and are related to worse memory function. Findings suggest that medial temporal cerebrovascular dysfunction is related to cognition and memory before the onset of dementia, independent of changes in Alzheimer pathophysiologic markers. Limitations of the study include the cross-sectional design. Future longitudinal studies are warranted to examine whether early cerebrovascular changes can predict progressive memory decline.
Authors
- Daniel A. Nation (ORCID: https://orcid.org/0000-0002-9123-0658)
- Fatemah Shenasa (ORCID: https://orcid.org/0000-0001-9030-4857)
- Allison C Engstrom (ORCID: https://orcid.org/0000-0002-4676-0430)
- Shubir Dutt (ORCID: https://orcid.org/0000-0002-8408-2220)
- Xingfeng Shao (ORCID: https://orcid.org/0000-0002-4130-6204)
- Trevor Lohman (ORCID: https://orcid.org/0000-0002-9634-702X)
- John Paul M Alitin (ORCID: https://orcid.org/0009-0001-5494-9639)
- Danny J.J. Wang (ORCID: https://orcid.org/0000-0002-0840-7062)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Arunima Kapoor (ORCID: https://orcid.org/0000-0003-4622-8951)
- Isabel J. Sible (ORCID: https://orcid.org/0000-0003-3922-0628)
- Aimée Gaubert (ORCID: https://orcid.org/0000-0001-6812-522X)
- David Bradford (ORCID: https://orcid.org/0000-0002-9611-0479)
- Anisa Marshall (ORCID: https://orcid.org/0000-0001-5457-2520)
- Kathleen E. Rodgers (ORCID: https://orcid.org/0000-0002-7994-8894)
- Lorena Sordo (ORCID: https://orcid.org/0000-0002-7016-6706)
Institutions
- University of Southern California (US)
- University of Arizona (US)
- University of California, San Francisco (US)
- University of California, Irvine (US)
- Keck Hospital of USC (US)
- Arizona Science Center (US)
- Center for Innovation (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1212/wnl.0000000000210210
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41