Targeted Next-Generation Sequencing of Cell-Free DNA to Detect <i>MYC</i> -Immunoglobulin Translocation and Epstein-Barr Virus DNA in Plasma of Burkitt Lymphoma Patients in East Africa
This analysis demonstrates the potential of liquid biopsy to improve BL diagnosis in settings with limited pathology resources. Validation of our approach in a larger data set is needed.
Authors
- Malale Tungu
- Atukuzwe Kahakwa
- Helene Marie-Pierre Dreau (ORCID: https://orcid.org/0000-0002-2532-4162)
- Jacqueline Kamanga
- Isaac Omara Otim (ORCID: https://orcid.org/0000-0001-8000-9483)
- Emmanuel Balandya (ORCID: https://orcid.org/0000-0002-3707-9985)
- Heavenlight Christopher (ORCID: https://orcid.org/0000-0001-7379-5877)
- Faraja Chiwanga (ORCID: https://orcid.org/0000-0003-0033-568X)
- Liberata Alexander Mwita (ORCID: https://orcid.org/0000-0002-5693-529X)
- Adam Burns (ORCID: https://orcid.org/0000-0002-8787-9147)
- Kate Ridout (ORCID: https://orcid.org/0000-0003-4685-1006)
- Caroline Achola (ORCID: https://orcid.org/0009-0004-4748-5102)
- Daisy Jennings (ORCID: https://orcid.org/0000-0003-4773-7977)
- Emmanuel Josephat
- Kieran Howard (ORCID: https://orcid.org/0000-0003-3335-4940)
- Liz Morrell (ORCID: https://orcid.org/0000-0001-6382-1795)
- Oliver Henke (ORCID: https://orcid.org/0000-0002-9838-9805)
- Daniel Mbwambo
- Pamela Atim
- Priscus John Mapendo (ORCID: https://orcid.org/0009-0006-6489-0374)
- Leah F. Mnango
- George Mugambage Ruhago (ORCID: https://orcid.org/0000-0001-7469-7822)
- Elifuraha Wilson Mkwizu (ORCID: https://orcid.org/0000-0001-5938-5628)
- Raphael Zozimus Sangeda (ORCID: https://orcid.org/0000-0002-6574-5308)
- Alex Mremi (ORCID: https://orcid.org/0000-0001-7226-0168)
- Sarah Wordsworth (ORCID: https://orcid.org/0000-0002-2361-3040)
- Anthony Cutts
- Lulu Chirande (ORCID: https://orcid.org/0009-0001-5008-3786)
- Ismail D. Legason (ORCID: https://orcid.org/0000-0002-6118-542X)
- Sam M. Mbulaiteye (ORCID: https://orcid.org/0000-0002-8273-9831)
- Edrick M. Elias (ORCID: https://orcid.org/0000-0002-7281-499X)
- Hadija Mwamtemi (ORCID: https://orcid.org/0009-0007-6501-535X)
- Anna Schuh (ORCID: https://orcid.org/0000-0002-3938-8490)
- William Frank Mawalla (ORCID: https://orcid.org/0000-0002-0016-7551)
- Patricia Scanlan
- Dimitris V. Vavoulis (ORCID: https://orcid.org/0000-0002-3984-1507)
- Clara C Chamba (ORCID: https://orcid.org/0000-0001-5154-7872)
- Kristin Schroeder (ORCID: https://orcid.org/0000-0002-6433-6174)
- Hadija Nabalende
- Paul Ntemi
- Julius Sseruyange
- Godlove Sandi (ORCID: https://orcid.org/0000-0001-9068-0991)
- Salama Mahawi
- Jingjing Jiang (ORCID: https://orcid.org/0000-0002-5646-6040)
- Laura Lopez Pascua
- Rehema Shungu
- Martin D. Ogwang
- Alisen Ayitwala
- Philomena Goodluck
- Erick Marogosa
- Claire El Moulden
- Mihaela Leonte
Institutions
- Muhimbili University of Health and Allied Sciences (TZ)
- University of Oxford (GB)
- St. Mary's Hospital Lacor (UG)
- Kilimanjaro Christian Medical Centre (TZ)
- Muhimbili National Hospital (TZ)
- Bugando Medical Centre (TZ)
Publication Details
- Journal
- JCO Global Oncology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1200/go.24.00210
- Citations
- 3
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.14