Dynamic Peptide Nanoframework-Guided Protein Coassembly: Advancing Adhesion Performance with Hierarchical Structures
Hierarchical structures are essential in natural adhesion systems. Replicating these in synthetic adhesives is challenging due to intricate molecular mechanisms and multiscale processes. Here, we report three phosphorylated peptides featuring a hydrophobic self-assembly motif linked to a hydrophilic phosphorylated sequence (pSGSS), forming peptide fibril nanoframeworks. These nanoframeworks effectively coassemble with elastin-derived positively charged proteins (PCP), resulting in complex coacervate-based adhesives with hierarchical structures. Our method enables the controlled regulation of both cohesion and adhesion properties in the adhesives. Notably, the complex adhesives formed by the dityrosine-containing peptide and PCP demonstrate an exceptional interfacial adhesion strength of up to 30 MPa, outperforming most known supramolecular adhesives and rivaling cross-linked chemical adhesives. Additionally, these adhesives show promising biocompatibility and bioactivity, making them suitable for applications such as visceral hemostasis and tissue repair. Our findings highlight the utility of bioinspired hierarchical assembly combined with bioengineering techniques in advancing biomedical adhesives.
Authors
- Qinrui Wang
- Han Wen (ORCID: https://orcid.org/0000-0003-4680-4218)
- Hongjie Zhang (ORCID: https://orcid.org/0000-0002-7175-5166)
- Yusai Zhou (ORCID: https://orcid.org/0000-0002-2560-3997)
- Qi Guo (ORCID: https://orcid.org/0000-0001-7993-0830)
- Bodan Deng
- Bo Jia (ORCID: https://orcid.org/0000-0002-7178-424X)
- Jing Yu (ORCID: https://orcid.org/0000-0002-4288-951X)
- Rong Chang (ORCID: https://orcid.org/0000-0002-5458-6612)
- Yong‐Xiang Chen (ORCID: https://orcid.org/0000-0003-3518-0139)
- Yubin Ren
- Bo Li (ORCID: https://orcid.org/0000-0002-3792-2469)
- Kai Liu (ORCID: https://orcid.org/0000-0003-0878-5191)
- Xinyan Wang (ORCID: https://orcid.org/0000-0002-3690-2335)
- Mengyao Wang (ORCID: https://orcid.org/0000-0002-2681-3873)
- Zhenyue Yang (ORCID: https://orcid.org/0000-0003-0089-3614)
- Hongliang Zhu (ORCID: https://orcid.org/0000-0002-9378-9236)
Institutions
- Union Hospital (HK)
- Nanyang Technological University (SG)
- Northeast Normal University (CN)
- Jilin University (CN)
- Chinese Academy of Sciences (CN)
- Changchun Institute of Applied Chemistry (CN)
- Beihang University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1021/jacs.4c10882
- Citations
- 16
- Primary Topic
- Supramolecular Self-Assembly in Materials
- Type
- article
- Field-Weighted Citation Impact
- 9.55
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Key Research and Development Program of China