Effect of Withania somnifera on Expression of Selected Genes in Hippocampus of Male Wistar Rats Subjected to Chronic Unpredictable Mild Stress
This study highlights the antidepressant effects of WS by demonstrating its effect on BDNF-associated gene expression. Fluoxetine combined with WS demonstrated additive effects which proves an adjuvant role of WS in the treatment of depression. Further studies involving human subjects are essential to validate the antidepressant effects of WS and its additive effects with fluoxetine.
Authors
- Urmila Anil Kagal (ORCID: https://orcid.org/0000-0003-2744-3824)
- Prakash R. Biradar (ORCID: https://orcid.org/0000-0001-5573-4595)
- J. P. Mehta (ORCID: https://orcid.org/0000-0003-3075-2732)
Institutions
- Jawaharlal Nehru Medical College (IN)
- KLE Academy of Higher Education and Research (IN)
Publication Details
- Journal
- International Journal of Applied and Basic Medical Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4103/ijabmr.ijabmr_330_24
- Primary Topic
- Phytochemicals and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00