Integrated bioinformatics analysis and experimental validation of exosome-related gene signature in steroid-induced osteonecrosis of the femoral head
Twenty potential exosome-related genes involved in SIONFH were identified through bioinformatics analysis. LCP1, PNP, UBE2V1, and ZFP36 might become candidate biomarkers and therapeutic targets because they have an intimate relationship with exosomes. These findings shed light on the exosome-related acquaintance of SIONFH and might contribute to the diagnosis and prognosis of SIONFH.
Authors
- Wenqing Li (ORCID: https://orcid.org/0009-0000-6591-9059)
- Wen Bi (ORCID: https://orcid.org/0000-0002-5613-6412)
- Renqun Mao (ORCID: https://orcid.org/0009-0000-8212-1401)
- Lei Qin (ORCID: https://orcid.org/0000-0003-2500-0181)
- Mengyue Yang (ORCID: https://orcid.org/0009-0007-6266-1014)
Institutions
- Shenzhen Sixth People's Hospital (CN)
- Shenzhen University Health Science Center (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s13018-025-05456-1
- Citations
- 2
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.44
Funders
- Guangdong Medical Research Foundation