NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Overall, NXP800 has antitumor activity against treatment-resistant prostate cancer models, including molecular subtypes with limited treatment options, supporting its consideration for prostate cancer-specific clinical development.

Authors

Institutions

Publication Details

Journal
Clinical Cancer Research
Published
2025-01-09
DOI
https://doi.org/10.1158/1078-0432.ccr-24-2386
Citations
7
Primary Topic
Heat shock proteins research
Type
article
Field-Weighted Citation Impact
5.64

Funders

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article

NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Paul Workman, Jonathan Welti, Matthew D. Cheeseman, Jyoti S. Choudhary et al.
7 citations
Clinical Cancer Research
Heat shock proteins research
5.64
article

NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer Growth

Paul Workman, Jonathan Welti, Matthew D. Cheeseman, Jyoti S. Choudhary, Veronica Gil, Bora Gürel, Amandeep Bhamra, Antje Neeb, Dapei Li, Ilona Bernett, Juan M. Jiménez‐Vacas, Udai Banerji, Ines Figueiredo, Paul Andrew Clarke, Mateus Crespo, Denisa Bogdan, Marissa Powers, Jan Rekowski, Amanda Swain, Nina Tunariu, Robert te Poele, Susana Miranda, Wei Yuan, Ana Ferreira, N. Chessum, Ruth Riisnaes, Peter S. Nelson, Adam Sharp, Claudia Bertan, Johann Sebastian De Bono, Lorenzo Buroni, Theodoros I. Roumeliotis, Elisa Pasqua, Ilsa M. Coleman, Jian Ning, Suzanne Carreira, Keith Jones, Wanting Zeng, Kate Liodaki, Franziska Weigl
article en
7 citations

Abstract

Overall, NXP800 has antitumor activity against treatment-resistant prostate cancer models, including molecular subtypes with limited treatment options, supporting its consideration for prostate cancer-specific clinical development.

Clinical Cancer ResearchVol. 31(6)
Royal Marsden NHS Foundation Trust (GB), Institute of Cancer Research (GB), University of Washington (US), Cancer Research UK (GB), Fred Hutch Cancer Center (US), Royal Marsden Hospital (GB), Boehringer Ingelheim (Egypt) (EG), Seattle University (US)
Medical Research Council
Good health and well-being
Openalex Percentile: Top 4%
Heat shock proteins research
5.64
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