Exploring the Profiles of ROS1 Tyrosine Kinase: A Structural Analysis of G2032R and D2033N Mutations
Our study constructed an initial model of the human ROS1 and used it for MD simulation studies to examine the conformational changes in ROS1 mutants. Notably, our observations revealed that the mutations caused deviations in the MD trajectory. The G2032R and D2033N mutations significantly alter ROS1 structure, affecting its stability and dynamics, offering key insights into their role in cancer disease development.
Authors
- Syed Ikramul Hasan (ORCID: https://orcid.org/0000-0002-4997-846X)
Institutions
- Al Baha University (SA)
Publication Details
- Journal
- International Journal of Applied and Basic Medical Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4103/ijabmr.ijabmr_43_24
- Citations
- 2
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.09