Alkaline phosphatase decline and pain response as predictors of overall survival benefit in patients treated with radium-223: a post hoc analysis of the REASSURE study
ClinicalTrials.gov identifier NCT02141438. Analyses from the radium-223 REASSURE global study suggest that declines in alkaline phosphatase and pain during treatment may predict longer survival in patients with advanced prostate cancer and may help doctors make decisions with their patients.
Authors
- Igle J. de Jong (ORCID: https://orcid.org/0000-0002-3444-5548)
- Sabina Dizdarevic (ORCID: https://orcid.org/0000-0002-6715-3744)
- Bertrand Tombal (ORCID: https://orcid.org/0000-0002-0093-8408)
- Nicholas David James (ORCID: https://orcid.org/0000-0002-7314-8204)
- Markus Essler
- Per Sandström (ORCID: https://orcid.org/0000-0002-8078-9528)
- Joe M. O’Sullivan (ORCID: https://orcid.org/0000-0001-6999-2739)
- Sergio Baldari (ORCID: https://orcid.org/0000-0002-4652-725X)
- Oliver A. Sartor (ORCID: https://orcid.org/0000-0002-8777-7343)
- Saby George (ORCID: https://orcid.org/0000-0002-0444-5870)
- Elena Castro (ORCID: https://orcid.org/0000-0002-3691-6454)
- Secondo Lastoria (ORCID: https://orcid.org/0000-0002-6649-9903)
- Daniel Heinrich (ORCID: https://orcid.org/0000-0002-7086-0562)
- Peter Hammerer
- Jeff Meltzer
Institutions
- Brighton and Sussex Medical School (GB)
- University of Messina (IT)
- Queen's University Belfast (GB)
- Roswell Park Comprehensive Cancer Center (US)
- Cliniques Universitaires Saint-Luc (BE)
- University Medical Center Groningen (NL)
- Institute of Cancer Research (GB)
- Bayer (United States) (US)
- University of Sussex (GB)
- Innlandet Hospital Trust (NO)
- University Hospital Bonn (DE)
- Hospital Universitario 12 De Octubre (ES)
- Mayo Clinic in Arizona (US)
- The Northern Ireland Cancer Centre (GB)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- University Hospitals Sussex NHS Foundation Trust (GB)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1038/s41416-024-02927-w
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Bayer
- Sanofi