A mutant complement factor H (W1183R) enhances proteolytic cleavage of von Willebrand factor by ADAMTS-13 under shear
These results demonstrate for the first time that W1183R-CFH but not WT-CFH protein enhances the proteolytic cleavage of VWF by ADAMTS-13 under shear. This may be achieved by mechanic-induced conformational changes of the central A2 domain, leading to an enhanced cleavage of Tyr<sup>1605</sup>-Met<sup>1606</sup> bond by ADAMTS-13 under pathophysiological conditions.
Authors
- X. Long Zheng (ORCID: https://orcid.org/0000-0003-1680-5295)
- Yi Liu (ORCID: https://orcid.org/0000-0001-5937-358X)
- Xiao Hui Zhang (ORCID: https://orcid.org/0000-0002-8778-595X)
- Wenjing Cao
Institutions
- University of Massachusetts Amherst (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1016/j.jtha.2024.11.031
- Citations
- 2
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Heart, Lung, and Blood Institute