Metabolites and coronary heart disease: A two sample Mendelian randomization
Our MR analysis demonstrated a protective effect of Phospholipids in medium HDL, and a potentially anti-protective effect of Free cholesterol in large LDL, Total cholesterol in medium LDL, Total cholesterol in LDL, Phospholipids in medium LDL, Total cholesterol in small VLDL, Triglycerides in small VLDL, Free cholesterol in small VLDL, Phospholipids in small VLDL, Triglycerides in small HDL, Alanine on the pathogenesis of CHD. Additional studies are required to translate the findings into practice.
Authors
- Tianjie Zhang (ORCID: https://orcid.org/0000-0002-6697-0777)
- Sheng Yang
- Wei Zhang
- Zhenyu Zhu (ORCID: https://orcid.org/0009-0001-3100-4325)
- Feng Gao
Institutions
- Tongde Hospital of Zhejiang Province (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- International Journal of Cardiology Cardiovascular Risk and Prevention
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1016/j.ijcrp.2025.200365
- Citations
- 2
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Zhejiang Medical Association