Assessing the neuroprotective benefits of Cannabis sativa in epilepsy management

• Rise of Cannabinoids in Neurological Treatment: Explores the increasing interest in cannabinoids, especially CBD, for managing neurological conditions, with a particular focus on epilepsy. • Endocannabinoid System and Mechanisms of Action: Highlights how cannabinoids interact with the endocannabinoid system, modulating neurotransmission, neuroprotection, and offering potential anticonvulsant effects. • Efficacy in Drug-Resistant Epilepsy : Summarizes evidence from clinical trials indicating that cannabinoids, especially Epidiolex, can significantly reduce seizure frequency in patients with drug-resistant epilepsy, including conditions like Dravet and Lennox-Gastaut syndromes. • Safety and Tolerability: Reviews findings on the safety profile of cannabinoids, discussing both potential side effects and current understanding of long-term safety concerns, particularly in pediatric populations. • Challenges and Controversies: Discusses the regulatory, ethical, and practical challenges associated with medical cannabis use, including the lack of standardized formulations and the varying psychoactive effects of cannabinoids. • Future Directions in Cannabinoid Research: Outlines key areas for future research, such as personalized medicine approaches, further clinical applications, development of standardized products, and optimizing delivery methods. Epilepsy is one of the most common neurological conditions worldwide. Cannabinoids, particularly cannabidiol (CBD) and tetrahydrocannabinol (THC), have demonstrated therapeutic potential in the treatment of epilepsy due to their interaction with the endocannabinoids system. Despite these developments, the use of medical cannabis is still complicated because of legal obstacles, the different psychoactive effects of different cannabinoid receptors, and concerns about long-term safety, especially in populations with young children. The development of new regulations will be essential to increasing access to patients' cannabis medications. Cannabis has the potential to change the therapeutic landscape for neurological illnesses like seizures, provided that science and regulation continue to progress.