The role and mechanism of HMGB1-mediated Notch1/Hes-1 pathway in anxiety and depression-like behaviors in mice with chronic rhinosinusitis
HMGB1 activates the microglial Notch1/Hes-1 pathway in CRS mice, promoting neuroinflammation and anxiety and depression-like behaviors. Metformin alleviates these effects.
Authors
- Jianyao Li (ORCID: https://orcid.org/0009-0008-4852-5443)
- Yangsong Li
- Tian Zhang (ORCID: https://orcid.org/0000-0002-0453-1621)
- Yiting Jiang (ORCID: https://orcid.org/0009-0001-0434-5204)
- Guodong Yu (ORCID: https://orcid.org/0000-0003-1139-9021)
- Fangwei Zhou (ORCID: https://orcid.org/0009-0006-9830-4281)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s10020-024-01057-6
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Health Commission of Guizhou Province
- National Natural Science Foundation of China