Effects of EGFR-TKIs combined with intracranial radiotherapy in EGFR-mutant non-small cell lung cancer patients with brain metastases: a retrospective multi-institutional analysis
This study demonstrated that upfront addition of SRS/fSRS to EGFR-TKIs was associated with longer OS compared to upfront WBRT or upfront TKI alone in EGFR-mutant NSCLC patients with BMs. This improvement was more significant in patients with L858R mutation and those treated with first or second-generation EGFR-TKIs. Further research with a larger sample size is warranted.
Authors
- Hengqiu He
- Mingfeng He (ORCID: https://orcid.org/0000-0002-2299-3635)
- Zaicheng Xu (ORCID: https://orcid.org/0000-0002-2870-1365)
- Ruiqin Zhou (ORCID: https://orcid.org/0000-0002-8995-3195)
- Zhenzhou Yang (ORCID: https://orcid.org/0000-0003-2496-1992)
- Guangming Yi
- Xue‐Ru Wu (ORCID: https://orcid.org/0000-0001-6058-6291)
- Li Li (ORCID: https://orcid.org/0000-0002-9702-4601)
- Ying Ye (ORCID: https://orcid.org/0000-0002-6886-8602)
- Yitian Wang
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s13014-024-02578-4
- Citations
- 2
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing