Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients
These findings offer crucial insights for clinicians evaluating candidates for anti-HER2 therapy, especially for HER2-low breast cancer patients who could gain from T-Dxd treatment. Identifying HNMT expression could help clinicians pinpoint patients who would benefit from anti-HER2 therapy.
Authors
- Chih‐Hsiung Wu
- Yun Yen (ORCID: https://orcid.org/0000-0003-0815-412X)
- Huey-En Tzeng (ORCID: https://orcid.org/0000-0002-9980-4361)
- You-Cheng Liao
- Li-Ching Chen (ORCID: https://orcid.org/0000-0003-4940-2791)
- Cheng‐Ying Chu (ORCID: https://orcid.org/0000-0003-1002-8640)
- Chi‐Long Chen (ORCID: https://orcid.org/0000-0003-2875-1669)
- Shih‐Hsin Tu (ORCID: https://orcid.org/0000-0002-4106-8146)
- Peixuan Guo (ORCID: https://orcid.org/0000-0001-5706-2833)
- Jacqueline Whang-Peng
- Mien‐Chie Hung (ORCID: https://orcid.org/0000-0003-4317-4740)
- Wen-Jui Lee
- Min‐Hsiung Pan (ORCID: https://orcid.org/0000-0002-5188-7030)
- Tzu‐Chun Cheng (ORCID: https://orcid.org/0009-0006-9922-331X)
- Yu-Ching Lee
- Yuan‐Soon Ho
- Hui-Kuan Lin
- Lu-Hai Wang
Institutions
- Asia University (TW)
- National Chung Hsing University (TW)
- National Taiwan University (TW)
- Duke University (US)
- China Medical University (TW)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Taipei Medical University Hospital (TW)
- Taichung Veterans General Hospital (TW)
- Duke Medical Center (US)
- Duke University Hospital (US)
- Taipei Medical University (TW)
- The Ohio State University (US)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s40364-024-00715-5
- Citations
- 3
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- Ministry of Education, India
- Taipei Medical University
- China Medical University
- National Science and Technology Council
- Taipei Medical University Hospital