Protein Alterations in Patients with Delirium after Cardiac Surgery: An Exploratory Case–Control Substudy of the VISION Cardiac Surgery Biobank
The study identified 26 biomarkers significantly associated with delirium; all are novel except for interleukin-8. An association between delirium and recognized neuroinflammatory proteins or markers of brain injury was not identifed, which supports using biomarkers to differentiate between delirium and other neurologic conditions. While exploratory, the study's findings support using biomarkers to diagnose postoperative delirium and validate using agnostic screens to identify potential delirium biomarkers.
Authors
- Katheryn Brady (ORCID: https://orcid.org/0000-0003-4764-5511)
- Chew Yin Wang (ORCID: https://orcid.org/0000-0002-9066-3830)
- Emilie P. Belley‐Côté (ORCID: https://orcid.org/0000-0002-5071-076X)
- Tao Sun
- Richard Paul Whitlock (ORCID: https://orcid.org/0000-0002-6863-5884)
- Matthew T.V. Chan (ORCID: https://orcid.org/0000-0002-3574-7855)
- Jessica Spence (ORCID: https://orcid.org/0000-0003-1267-9455)
- P.J. Devereaux (ORCID: https://orcid.org/0000-0003-2935-637X)
- Guillaume Paré (ORCID: https://orcid.org/0000-0002-6795-4760)
- William F. McIntyre (ORCID: https://orcid.org/0000-0001-6082-7542)
- Michael Chong (ORCID: https://orcid.org/0000-0002-0555-4622)
- Andre L. Lamy (ORCID: https://orcid.org/0000-0003-2777-7621)
- Shaheena Bashir
Institutions
- Chinese University of Hong Kong (HK)
- Population Health Research Institute (CA)
- University of Malaya (MY)
- Thrombosis and Atherosclerosis Research Institute (CA)
- Impact (CA)
- Hamilton Health Sciences (CA)
- McMaster University (CA)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1097/aln.0000000000005368
- Citations
- 3
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.64