The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly
This is the first report to demonstrate an association between a novel parameter of brain-systemic oxygenation coherence in SDB and cognition in older adults. A higher coherence rate of cortical oxy-Hb and systemic SpO<sub>2</sub> during SDB may reflect a loss of compensatory mechanisms against systemic hypoxia and could help stratify older adults with a higher risk for cognitive decline.
Authors
- Makoto Kawai (ORCID: https://orcid.org/0000-0001-9176-4388)
- Kai Parker-Fong (ORCID: https://orcid.org/0000-0002-6061-3517)
- Pahnwat Taweesedt (ORCID: https://orcid.org/0000-0002-5791-6920)
- S. M. Hadi Hosseini (ORCID: https://orcid.org/0000-0001-5186-7008)
- Casey Buck
- Rosy Karna
Institutions
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1038/s41598-024-84305-3
- Citations
- 2
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Academy of Medicine
- National Institute of Mental Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Stanford Maternal and Child Health Research Institute