Stereo- and Enantioselective Syntheses of (<i>Z</i>)-1,3-Butadienyl-2-carbinols via Brønsted Acid Catalysis
A Brønsted acid-catalyzed enantioselective synthesis of (<i>Z</i>)-1,3-butadienyl-2-carbinols is developed. By employing a chiral phosphoric acid as the catalyst, a variety of 1,3-butadienyl-2-carbinols were obtained in good yields with excellent <i>Z</i>-selectivities and enantiopurities from α-alkyl-substituted homoallenyl boronates.
Authors
- Ming Chen (ORCID: https://orcid.org/0000-0002-9841-8274)
Institutions
- Virginia Tech (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1021/acs.orglett.4c04663
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Division of Chemistry