High prevalence of reverse transcriptase inhibitors associated resistance mutations among people living with HIV on dolutegravir-based antiretroviral therapy in Francistown, Botswana
A high but similar prevalence of any DRMs was observed among individuals with LLV and those with VF on dolutegravir-based therapy. Monitoring DRMs in individuals with detectable VL is crucial for preserving dolutegravir-based ART.
Authors
- Catherine K. Koofhethile (ORCID: https://orcid.org/0000-0001-5475-413X)
- Rosemary Musonda (ORCID: https://orcid.org/0009-0009-9937-6908)
- Tony Chebani
- Simani Gaseitsiwe (ORCID: https://orcid.org/0000-0002-7089-3735)
- Dorcas Maruapula (ORCID: https://orcid.org/0000-0003-2587-8904)
- Irene Gobe (ORCID: https://orcid.org/0000-0003-3679-6509)
- Roger Shapiro (ORCID: https://orcid.org/0000-0002-4832-6275)
- Shahin Lockman (ORCID: https://orcid.org/0000-0002-5384-9716)
- Modisa S. Motswaledi (ORCID: https://orcid.org/0000-0001-8163-7166)
- Mpaphi B. Mbulawa
- Natasha O. Moraka (ORCID: https://orcid.org/0000-0001-5333-4010)
- Boitumelo Zuze (ORCID: https://orcid.org/0009-0005-5283-7763)
- Ontlametse T. Bareng (ORCID: https://orcid.org/0009-0005-8147-2193)
- Joseph Makhema (ORCID: https://orcid.org/0000-0003-0017-2438)
- Kedumetse Seru (ORCID: https://orcid.org/0009-0005-9456-6367)
- Wonderful Tatenda Choga (ORCID: https://orcid.org/0000-0001-7606-0569)
- Sikhulile M. Moyo (ORCID: https://orcid.org/0000-0003-3821-4592)
- Patrick Mokgethi
- Patience Montshosi
- Goitseone Martha Lemogang
- Judith Nawa
- Lindani Bochena
- Gaonyadiwe Muzanywa
- Thembinkosi M Shadreck
- Charity Ralegoreng
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Botswana (BW)
- Stellenbosch University (ZA)
- Ministry of Health (BW)
- Botswana Harvard AIDS Institute Partnership (BW)
- Nyangabgwe Referral Hospital (BW)
- University of Pretoria (ZA)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/jac/dkae472
- Citations
- 4
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.56