Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans
Overall, our findings reveal that the addition of AF to plasma enhances coagulation in a manner dependent on phospholipids as well as the presence of proteases and other proteins that directly regulate coagulation. We describe a correlation between clotting time and expression of coagulation proteins and phosphatidylserine in both rhesus and human AF, supporting the use of rhesus models for future studies of AF biology.
Authors
- Ashley E. Benson (ORCID: https://orcid.org/0000-0001-5716-2818)
- Kilsun Kim
- Joseph E. Aslan (ORCID: https://orcid.org/0000-0002-8873-0387)
- Phillip A. Wilmarth (ORCID: https://orcid.org/0000-0002-7559-8727)
- Chaevien Clendinen (ORCID: https://orcid.org/0000-0002-1487-4126)
- Owen J. T. McCarty (ORCID: https://orcid.org/0000-0001-9481-0124)
- Ashok P. Reddy (ORCID: https://orcid.org/0000-0003-1967-6927)
- Olivia L. Hagen (ORCID: https://orcid.org/0009-0001-0369-5819)
- Jamie O. Lo (ORCID: https://orcid.org/0000-0002-1934-1935)
- Keith Zientek (ORCID: https://orcid.org/0000-0002-3601-3714)
- Joseph J. Shatzel (ORCID: https://orcid.org/0000-0001-9396-5976)
- Lisa Bramer (ORCID: https://orcid.org/0000-0002-8384-1926)
- Lyndsey E. Shorey‐Kendrick (ORCID: https://orcid.org/0000-0001-8060-0097)
- Cristina Puy (ORCID: https://orcid.org/0000-0002-5911-8156)
- Helen H. Vu
- Brian P. Scottoline (ORCID: https://orcid.org/0000-0003-0207-9624)
- Adam Crosland (ORCID: https://orcid.org/0000-0002-7918-197X)
- Chih Jen Yang
Institutions
- Oregon National Primate Research Center (US)
- Pacific Northwest National Laboratory (US)
- Oregon Health & Science University (US)
- Environmental Molecular Sciences Laboratory (US)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.rpth.2024.102676
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- Foundation for the National Institutes of Health
- March of Dimes Foundation
- National Institutes of Health
- Oregon National Primate Research Center
- National Institute on Drug Abuse