Associations Between Walking Pace, APOE-ε4 Genotype, and Brain Health in Middle-Aged to Older Adults
These results suggest walking pace and APOE-ε4 status independently influence brain volume outcomes, but both factors independently and jointly contribute to increased dementia risk. Individuals with both risk factors (slow walking pace and APOE-ε4 allele) show the strongest associations with dementia risk.
Authors
- Mark H. C. Lai (ORCID: https://orcid.org/0000-0002-9196-7406)
- Gene E. Alexander (ORCID: https://orcid.org/0000-0002-6476-5606)
- Daniel H. Aslan (ORCID: https://orcid.org/0000-0002-3694-7218)
- M. Katherine Sayre (ORCID: https://orcid.org/0000-0003-2554-4058)
- David A. Raichlen (ORCID: https://orcid.org/0000-0002-4940-7886)
- Pradyumna K. Bharadwaj
- Yann C. Klimentidis (ORCID: https://orcid.org/0000-0002-6065-4044)
- Rand R. Wilcox (ORCID: https://orcid.org/0000-0002-2524-2976)
- Silvio Maltagliati (ORCID: https://orcid.org/0000-0001-7199-0599)
- Madeline Ally
Institutions
- University of Southern California (US)
- Alzheimer's Association (US)
- University of Arizona (US)
- University of California, Santa Barbara (US)
Publication Details
- Journal
- Medicine & Science in Sports & Exercise
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1249/mss.0000000000003646
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00