Evaluating the radiosensitivity of the oral microbiome to predict radiation-induced mucositis in head and neck cancer patients: A prospective trial
It is necessary to establish reliable predictors of severe OM before treatment in H&N cancer to allow early management of treatment-related sequelae. This prospective trial illustrates that the intrinsic <i>ex-vivo</i> radiosensitivity of oral keratinocytes could be correlated with RT-induced OM in patients with H&N cancer. This novel predictor requires validation in larger prospective cohorts.
Authors
- Jörg Sahlmann (ORCID: https://orcid.org/0000-0003-3023-3318)
- Elsa Beatriz Monroy Ordonez
- M. Henke (ORCID: https://orcid.org/0000-0003-0673-3873)
- Andreas Thomsen (ORCID: https://orcid.org/0000-0002-0163-8677)
- Anca-Ligia Grosu (ORCID: https://orcid.org/0000-0003-2255-2255)
- Benedikt Luka (ORCID: https://orcid.org/0000-0002-4832-6750)
- Henning Schäfer (ORCID: https://orcid.org/0000-0002-5948-5095)
- Vivek Verma (ORCID: https://orcid.org/0000-0002-5863-6023)
- Nadine Schlueter (ORCID: https://orcid.org/0000-0001-6414-8950)
- Tanja Sprave (ORCID: https://orcid.org/0000-0003-4052-6632)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- University Medical Center Freiburg (DE)
- Medizinische Hochschule Hannover (DE)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1016/j.ctro.2025.100915
- Citations
- 3
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Bundesministerium für Bildung und Forschung
- Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie