Arachidonic acid synergizes with aspirin preventing myocardial ischaemia–reperfusion injury and mitigates bleeding risk
AA synergizes with aspirin in protecting against MI/R injury, while minimizing the related bleeding risk, a major concern for patients with acute myocardial infarction. This is attributable to the selective augmentation of PGI2 and PGE2 that is amplified by TXA2 suppression by aspirin, underscoring improved microcirculation and ameliorated inflammation.
Authors
- Shaletanati Talabieke
- Dekun Zhu (ORCID: https://orcid.org/0000-0001-9653-3538)
- Zengrong Chen
- Garret A. FitzGerald (ORCID: https://orcid.org/0000-0002-5885-6819)
- De‐Pei Liu (ORCID: https://orcid.org/0000-0002-2636-4297)
- Haojie Rao (ORCID: https://orcid.org/0009-0006-9156-2480)
- Pengfei Xu (ORCID: https://orcid.org/0000-0002-9401-9487)
- Huihui Li (ORCID: https://orcid.org/0000-0001-6004-3086)
- Miao Wang (ORCID: https://orcid.org/0000-0002-0532-6312)
- Hong Chen (ORCID: https://orcid.org/0000-0003-3478-6139)
- Xu Zhang (ORCID: https://orcid.org/0000-0002-4356-0281)
- Qing Wan (ORCID: https://orcid.org/0009-0006-6348-7006)
- Xuejian Yang (ORCID: https://orcid.org/0009-0001-0447-8111)
- Jianfeng Yang
- Yifei Wu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Translational Therapeutics (United States) (US)
- Zhengzhou Central Hospital (CN)
- Fu Wai Hospital (CN)
- Tianjin Medical University (CN)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1093/cvr/cvae254
- Citations
- 8
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 11.77
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- National Key Research and Development Program of China