Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway
This study is the first to demonstrate the role of the gut microbiota-derived metabolite TMAO in prostate cancer. TMAO promotes the proliferation and migration of prostate cancer cells by activating the p38 pathway and increasing HMOX1 expression. Reducing choline intake through dietary intervention may delay the onset and progression of prostate cancer, presenting significant clinical application value.
Authors
- Yang Shen (ORCID: https://orcid.org/0000-0002-3313-5062)
- Chaowei Fu (ORCID: https://orcid.org/0000-0003-0966-8552)
- Jing Lv
- Yuwei Zhang (ORCID: https://orcid.org/0000-0003-1337-1081)
- Bo Liu (ORCID: https://orcid.org/0000-0003-3900-9486)
- Shengkai Jin
- Yuhua Zhou (ORCID: https://orcid.org/0009-0008-1557-963X)
- Ninghan Feng
- Menglu Li
Institutions
- Jiangnan University (CN)
- Nantong University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-01-09
- DOI
- https://doi.org/10.3389/fphar.2024.1526051
- Citations
- 8
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Wuxi Municipal Bureau on Science and Technology