DEFINITIONS OF THE BODY'S IMMUNE RESPONSE AS A CONSEQUENCE OF THE ACTION OF THE SARS-COV-2 IN THE "MOTHER-NEWBORN" SYSTEM

Background. The issue of the pandemic has become a key issue for the whole world over the past 5 years. The immune system plays a significant role in protecting the body against infections. In infants, it is immature at birth and functionally inferior. In the process of growth and development of the child's body, the mechanisms of protection of the child from various factors of the external environment change and ensure the harmonious growth and development of the child. Aim: To improve the study of the mechanisms of action of the SARS-COV-2 virus in the "mother-fetus-newborn" system from women who contracted COVID-19 during pregnancy and to summarize information on the features of postnatal adaptation of newborns from the mothers of this group. Materials and methods. The domestic and foreign professional research literature during the outbreak of the SARS-COV-2 virus was analyzed. In addition, the histories of childbirth and the development of newborns from mothers who contracted COVID-19 during pregnancy were retrospectively analyzed. Results. The obtained data and the study of the "virus-host" interaction mechanism supplement and improve knowledge about the impact of COVID-19 on pregnancy and the vital parameters of the newborn and the mechanisms of protection against it. Conclusions. Understanding the pathogenesis, mechanism of action and consequences of damage to the body tissues of newborns by the SARS-COV-2 virus in the "mother-fetus-newborn" system, studying the immune mechanisms of child protection, will help to prevent and avoid significant damage to the organs and systems of infants. The development of algorithms to protect newborns from the effects of the coronavirus will help preserve the child's health in the future.