Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan
Collectively, our data indicate that DG modification by Pomt1/2 results in core M3 capped with matriglycan, and that this is required to reinforce the sarcolemma and enable skeletal muscle health and neuromuscular strength.
Authors
- Tobias Willer
- Jeffrey M. Hord (ORCID: https://orcid.org/0000-0003-1343-5938)
- David Venzke (ORCID: https://orcid.org/0000-0001-8180-9562)
- Matthew M. Goddeeris (ORCID: https://orcid.org/0000-0001-6346-7220)
- Kevin P. Campbell (ORCID: https://orcid.org/0000-0003-2066-5889)
- Sarah S. Burns (ORCID: https://orcid.org/0000-0002-6907-2366)
Institutions
- University of Iowa (US)
- Howard Hughes Medical Institute (US)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s13395-024-00370-2
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Howard Hughes Medical Institute
- Amicus Therapeutics
- National Institutes of Health