An integrated investigation of mitochondrial genes in COPD reveals the causal effect of NDUFS2 by regulating pulmonary macrophages
Our study established the causal linkage between mitochondrial malfunctions and COPD, providing a potential therapeutic avenue to alleviate pulmonary inflammation accounting for COPD by targeting mitochondria-related genes. NDUFS2, a canonical component of mitochondrial electron respiratory chain, was highlighted instrumental for the susceptibility of risk-exposed individuals to COPD.
Authors
- Qiqing Huang (ORCID: https://orcid.org/0000-0002-3354-4800)
- Shaoran Shen
- Chenxi Cao (ORCID: https://orcid.org/0000-0002-6668-4164)
- Jianqing Wu (ORCID: https://orcid.org/0000-0003-0030-201X)
- Xiaoli Zou (ORCID: https://orcid.org/0009-0006-6468-9195)
- Tutu Kang
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1186/s13062-025-00593-3
- Citations
- 2
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province