A multicenter retrospective study of early cardiac toxicity in operable breast cancer patients receiving concurrent dual or mono anti-HER2 therapy with postoperative radiation therapy
Compared with trastuzumab-only, dual anti-HER2 therapy does not increase early cardiac toxicity in combination with postoperative RT in BC patients. Cardiac radiation exposure remains the primary risk factor for early toxicity.
Authors
- Wei‐Xiang Qi (ORCID: https://orcid.org/0000-0001-5484-3343)
- Lu Cao (ORCID: https://orcid.org/0000-0001-6644-0963)
- Rong Cai (ORCID: https://orcid.org/0000-0001-6793-5765)
- Lin Qing
- Jian Wu (ORCID: https://orcid.org/0000-0002-3394-1507)
- Jiayi Chen (ORCID: https://orcid.org/0000-0001-6417-290X)
- Ming Ye (ORCID: https://orcid.org/0000-0002-1085-4400)
- Qiwei Zhu
- Hong Wu (ORCID: https://orcid.org/0000-0002-9068-7699)
- Bo Yu (ORCID: https://orcid.org/0000-0001-6039-4249)
- Mengyun Zhou (ORCID: https://orcid.org/0000-0001-8095-7133)
- Huaying Xie (ORCID: https://orcid.org/0000-0002-3192-2353)
- Gang Cai (ORCID: https://orcid.org/0000-0003-3323-1932)
- Yuan Yao
- Jing Yang (ORCID: https://orcid.org/0000-0003-2021-3065)
Institutions
- Nantong University (CN)
- Renji Hospital (CN)
- Ruijin Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Jiangyin People's Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Changzhou No.2 People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- The Breast
- Published
- 2025-01-09
- DOI
- https://doi.org/10.1016/j.breast.2025.103879
- Citations
- 4
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- National Key Research and Development Program of China