Phosphorous-containing, amphiphilic ABB′ copolymers as siRNA nanocarriers with enhanced stability, reduced <i>in vitro</i> cytotoxicity, and efficient knockdown ability for the treatment of ocular diseases
Using phosphorus-containing, cationic polymers synthesized by REM-GTP, novel siRNA delivery agents were developed that demonstrate excellent siRNA encapsulation and efficient endosomal escape and gene silencing, while showing low cytotoxicity.
Authors
- Iris Kachel
- Friederike Adams (ORCID: https://orcid.org/0000-0002-4362-0387)
- Sven Schnichels (ORCID: https://orcid.org/0000-0002-2385-5517)
- José Hurst (ORCID: https://orcid.org/0000-0002-8697-2569)
- Moritz Kränzlein (ORCID: https://orcid.org/0000-0001-9851-0735)
- Philipp Weingarten (ORCID: https://orcid.org/0009-0005-0507-9509)
- Molly Tzu-Yu Lin
- Agens Fietz
Institutions
- University of Stuttgart (DE)
- STZ eyetrial (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- RSC Applied Polymers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4lp00321g
- Citations
- 3
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Bundesministerium für Bildung und Forschung
- Studienstiftung des Deutschen Volkes