<italic>Gynostemma pentaphyllum</italic> ethanol extract ameliorates motor dysfunction in a Parkinson<bold>’</bold>s disease mouse model through inhibiting neuronal apoptosis
The results indicate that GP might increase dopamine and serotonin levels in the midbrain and promote the survival of dopaminergic neurons in substantia nigra pars reticulata by regulating the expression of phosphorylation of MAPK family proteins and the expression of mitochondrial apoptosis-related proteins, thereby ameliorating motor deficits in PD mice.
Authors
- Sen Yan (ORCID: https://orcid.org/0000-0003-4889-1570)
- Ling Zeng (ORCID: https://orcid.org/0000-0002-9640-9083)
- Lei He (ORCID: https://orcid.org/0000-0002-4078-2081)
- Chong Zhang (ORCID: https://orcid.org/0000-0001-9609-8855)
- Tingting Zhao (ORCID: https://orcid.org/0000-0001-6418-699X)
- Peiwen Fan (ORCID: https://orcid.org/0000-0001-5957-674X)
Institutions
- Institute of Cognitive and Brain Sciences (US)
- Communication University of Zhejiang (CN)
- Institute of Cognitive Sciences and Technologies (IT)
Publication Details
- Journal
- Journal of Zhejiang University (Medical Sciences)
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3724/zdxbyxb-2024-0218
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Zhejiang Province