Single-cell analysis of lung epithelial cells reveals age and cell population-specific responses to SARS-CoV-2 infection in ciliated cells
This work reveals age dependent differences in the lung epithelial cell response to SARS-CoV-2 infection. The results can be used to identify drug targets to modulate molecular signaling cascades that mediate an innate immune response.
Authors
- Christopher Anderson (ORCID: https://orcid.org/0000-0002-8560-3438)
- Raven M. Osborn (ORCID: https://orcid.org/0000-0002-6835-8856)
- Juilee Thakar (ORCID: https://orcid.org/0000-0003-4479-4183)
- Stephen Dewhurst (ORCID: https://orcid.org/0000-0001-7729-7920)
- Chin‐Yi Chu (ORCID: https://orcid.org/0000-0002-2390-3937)
- Thomas J. Mariani (ORCID: https://orcid.org/0000-0001-5944-1298)
- Justin M. Leach (ORCID: https://orcid.org/0000-0003-0167-9097)
Institutions
- University of Rochester (US)
Publication Details
- Journal
- Clinical & Experimental Immunology
- Published
- 2024-12-06
- DOI
- https://doi.org/10.1093/cei/uxae118
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Rochester
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences