Single-cell transcriptomics identifies the common perturbations of monocyte/macrophage lineage cells in inflammaging of bone marrow
Our study revealed shared genes and ligand-receptor pairs in the activated monocyte/macrophage lineage within inflammaging bone marrow. These findings offer potential therapeutic targets for cell-specific anti-inflammatory treatments.
Authors
- Junjie Gao (ORCID: https://orcid.org/0000-0003-4820-8524)
- Yafei Lu (ORCID: https://orcid.org/0009-0000-6931-2852)
- Yao Meng (ORCID: https://orcid.org/0000-0003-0386-6267)
- Peng Liao (ORCID: https://orcid.org/0000-0002-4583-5285)
- Bingqi Wang (ORCID: https://orcid.org/0000-0002-7692-4299)
- Lin Du (ORCID: https://orcid.org/0000-0003-2990-1120)
- Changqing Zhang (ORCID: https://orcid.org/0000-0002-7408-4126)
- Fang Ye (ORCID: https://orcid.org/0000-0001-8507-0734)
- Delin Liu (ORCID: https://orcid.org/0000-0002-4451-2652)
- Zhigang Zhong (ORCID: https://orcid.org/0000-0003-4654-847X)
- Jiong Mei (ORCID: https://orcid.org/0000-0002-2378-5694)
- Sihan Tong
Institutions
- Shanghai Jiao Tong University (CN)
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shanghai Sixth People's Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jot.2024.09.013
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39