Inter‐Institutional Dynamics and Impact of Fluconazole‐Resistant <i>Candida parapsilosis</i>
We found high rates of fluconazole resistance in C. parapsilosis, attributable to nosocomial spread of hospital-specific clones bearing the Y132F substitution. Fluconazole resistance was associated with a higher risk of microbiological but not clinical failure. Strategies to limit nosocomial transmission of C. parapsilosis are needed.
Authors
- Naama Mizrahi
- Shelley Reich
- Dafna Yahav (ORCID: https://orcid.org/0000-0003-3181-9791)
- Ronen Ben‐Ami (ORCID: https://orcid.org/0000-0003-0628-0798)
- Maya Korem (ORCID: https://orcid.org/0000-0003-3276-0963)
- Miriam Weinberger (ORCID: https://orcid.org/0009-0008-0251-5813)
- Galia Rahav (ORCID: https://orcid.org/0000-0003-4039-0958)
- Anna Novikov (ORCID: https://orcid.org/0009-0002-6389-1288)
Institutions
- Tel Aviv University (IL)
- Hebrew University of Jerusalem (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Sheba Medical Center (IL)
- Hadassah Medical Center (IL)
- Rabin Medical Center (IL)
- Assaf Harofeh Medical Center (IL)
Publication Details
- Journal
- Mycoses
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1111/myc.70017
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00